Table 3.

Candidate SNP markers of aggressiveness as a symptom of hereditary diseases (these markers may change the TBP–DNA affinity)

Gene	dbSNP [12] or see [Reference]	5′ flank	$\frac{\mathbf{wt}}{mut}$	3′ flank	KD, nM		Z-score		Known diseases (observations) [Reference] or hypothetical ones in the case of the candidate SNP markers predicted by us in [this work] (see Methods: Additional file 2 : Figure S1)	[Ref] or [this work]
					$\frac{\mathbf{wt}}{mut}$	Δ	Z	α
ESR2	rs35036378	cctctcggtc	$\frac{\mathbf{t}}{g}$	ttaaaaggaa	$\frac{\mathbf{6}}{\mathit{8}}$	↓	5	10−3	ESR2-deficient pT1 tumor,	[116]
									(hypothetically) ESR2-deficient maladaptive aggressive social behaviors caused by bisphenol A and phthalates in children (primary tumors and aggression are well-known consequences of environmental pollution with bisphenol A)	[this work] [117, 118]
	rs766797386	ttaaaaggaa	$\frac{\mathbf{g}}{t}$	aaggggctta	$\frac{\mathbf{6}}{\mathit{7}}$	↓	3	10−2
HBB	rs397509430	gggctgggca	$\frac{\mathbf{t}}{-}$	atacaacagt	$\frac{\mathbf{5}}{\mathit{29}}$	↓	34	10−6	Malaria resistance, thalassemia, and also (hypothetically) thalassemia-related higher male–male aggression, socialized aggression, inattention, low IQ, acute psychosis with aggression, impulsiveness as a form of aggressiveness; aggression as a comorbidity in 4-yo and 5-yo girls and in boys with thalassemia in a hospital; aggressiveness as a consequence of regular hemodialysis in a severe form of thalassemia	[119] [this work] [85, 120–125]
	rs33980857	gggctgggca	$\frac{\mathbf{t}}{a,g,c}$	atacaacagt	$\frac{\mathbf{5}}{\mathit{21}}$	↓	27	10−6
	rs34598529	ggctgggcat	$\frac{\mathbf{a}}{g}$	aaagtcaggg	$\frac{\mathbf{5}}{\mathit{18}}$	↓	24	10−6
	rs33931746	gctgggcata	$\frac{\mathbf{a}}{g,c}$	aagtcagggc	$\frac{\mathbf{5}}{\mathit{11}}$	↓	14	10−6
	rs33981098	agggctgggc	$\frac{\mathbf{a}}{g,c}$	taaaagtcag	$\frac{\mathbf{5}}{\mathit{9}}$	↓	10	10−6
	rs34500389	cagggctggg	$\frac{\mathbf{c}}{a,t,g}$	ataaaagtca	$\frac{\mathbf{5}}{\mathit{6}}$	↓	3	10−2
(HBD)	rs35518301	caggaccagc	$\frac{\mathbf{a}}{g}$	taaaaggcag	$\frac{\mathbf{4}}{\mathit{8}}$	↓	11	10−6
HBB	rs63750953	ctgggcataa	$\frac{\mathbf{aa}}{-}$	gtcagggcag	$\frac{\mathbf{5}}{\mathit{8}}$	↓	9	10 −6	(hypothetically)malaria resistance, thalassemia, thalassemia-related higher male–male aggression, socialized aggression, inattention, low IQ, acute psychosis with aggression, impulsiveness as a form of aggressiveness; aggression as a comorbidity in 4-yo and 5-yo girls and in boys with thalassemia in a hospital; aggressiveness as a consequence of regular hemodialysis in a severe form of thalassemia	[this work] [85, 119, 125]
	rs281864525	tgggcataaa	$\frac{\mathbf{a}}{c}$	gtcagggcag	$\frac{\mathbf{5}}{\mathit{7}}$	↓	7	10 −6
(HBD)	rs34166473	aggaccagca	$\frac{\mathbf{t}}{c}$	aaaaggcagg	$\frac{\mathbf{4}}{\mathit{8}}$	↓	18	10 −6