. 2016 Dec 28;17(Suppl 14):995. doi: 10.1186/s12864-016-3353-3

Table 4.

Candidate SNP markers of obesity-related aggressiveness (these markers may change the TBP–promoter affinity)

Gene	dbSNP [12] or see [Reference]	5′ flank	$\frac{wt}{m u t}$	3′ flank	K_D, nM		Z-score		Known diseases (observations) [Reference] or hypothetical ones in the case of the candidate SNP markers predicted by us in [this work] (see Methods: Additional file 2 : Figure S1)	[Ref] or [this work]
Gene	dbSNP [12] or see [Reference]	5′ flank	$\frac{wt}{m u t}$	3′ flank	$\frac{wt}{m u t}$	Δ	Z	α		[Ref] or [this work]
PGR	rs10895068	gggagataaa	$\frac{g}{a}$	gagccgcgtg	$\frac{10}{6}$	↑	8	10⁻⁶	Endometrial cancer in obese women [de novo pathogenic TATA box], and also (hypothetically) obese school-aged girls show verbal aggressiveness (e.g., victimization); obese females are more aggressive (primate model); obesity and aggression coexist in polycystic ovary syndrome in women with biliary calculi (retrospective clinical reviews); high aggression/rejection in reproductive behavior (mice); low attraction and high aggression against males in females (rabbit model)	[126], [this work] [127–132]
LEP	rs201381696	tcgggccgct	$\frac{a}{g}$	taagaggggc	$\frac{4}{12}$	↓	17	10⁻⁶	(hypothetically) obesity and also, in a 10 yo girl, aggressiveness is a predictive factor for prevention of obesity in adolescence with cardiovascular complications in adulthood, as is the case for 5 yo boys (retrospective review); aberrant maternal behavior, low aggression against an unknown social stimulus and locomotor activity during a high-fat diet (mice); low chance to be dominant due to aggressiveness against subordinates in female social behavior (macaques model), high risks of suicidality, violence, and impulsive aggressiveness in 19–45 yo patients with schizophrenia; higher social aggressiveness in males (rat model); longer survival in aggressive leptin-deficient women with anorexia nervosa	[this work], [115, 134–143]
	rs200487063	tgatcgggcc	$\frac{g}{a}$	ctataagagg	$\frac{4}{2}$	↑	6	10⁻⁶	(hypothetically) obesity-caused hypertension, and also, lower risk of aberrant maternal behavior, higher aggression against an unknown social stimulus, and locomotion activity on a high-fat diet (mice); higher chance to be dominant due to aggressiveness against subordinates in female social behavior (macaque model); lower risks of suicidality, violence, and impulsive aggressiveness in 19–45 yo schizophrenic patients; lower social aggressiveness in males (rat model)	[this work] [115, 134–142]
	rs34104384	ccgctataag	$\frac{a}{t}$	ggggcgggca	$\frac{4}{3}$	↑	4	10⁻²		[this work] [115, 134–142]