Table 2.
Genes differentially expressed in ISIAH and WAG adrenal glands and referred to in Rat Genome Database as associated with metabolic diseases
| Gene symbol | Gene_ID | log2 (fold_change) ISIAH/WAG |
Gene definition |
|---|---|---|---|
| Abca1 a b d e | 313210 | 1.12 | ATP-binding cassette, subfamily A (ABC1), member 1 |
| Abcg2 | 312382 | 1.09 | ATP-binding cassette, subfamily G (WHITE), member 2 |
| Acacb a | 116719 | 0.98 | acetyl-CoA carboxylase beta |
| Acad9 | 294973 | 0.63 | acyl-CoA dehydrogenase family, member 9 |
| Acadsb | 25618 | −0.71 | acyl-CoA dehydrogenase, short/branched chain |
| Acot2 | 192272 | −0.55 | acyl-CoA thioesterase 2) |
| Acp5 | 25732 | −1.54 | acid phosphatase 5, tartrate resistant |
| Ada c | 24165 | 0.75 | adenosine deaminase |
| Adipoq a d | 246253 | 1.10 | adiponectin, C1Q and collagen domain containing |
| Adrb3 a | 25645 | 2.44 | adrenergic, beta-3-, receptor |
| Adssl1 | 684425 | 0.91 | adenylosuccinate synthase like 1 |
| Agt a | 24179 | 2.28 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
| Ahsg a d | 25373 | detected only in ISIAH rats | alpha-2-HS-glycoprotein |
| Aif1 | 29427 | 0.95 | allograft inflammatory factor 1 |
| Ak1 | 24183 | −0.72 | adenylate kinase 1 |
| Alas1 | 65155 | 0.75 | aminolevulinate, delta-, synthase 1 |
| Alpl a b d | 25586 | −1.32 | alkaline phosphatase, liver/bone/kidney |
| Anxa5 | 25673 | −0.97 | annexin A5 |
| Aox1 | 54349 | 1.74 | aldehyde oxidase 1 |
| Apoc1 d | 25292 | −0.90 | apolipoprotein C-I |
| Aqp1 | 25240 | −0.49 | aquaporin 1 |
| Arsb | 25227 | −0.49 | arylsulfatase B |
| Aspa | 79251 | 1.01 | aspartoacylase |
| Atp1a2 a | 24212 | 1.26 | ATPase, Na+/K+ transporting, alpha 2 polypeptide |
| Bche a d | 65036 | 1.32 | butyrylcholinesterase |
| C1qa | 298566 | 0.77 | complement component 1, q subcomponent, A chain |
| C3 a | 24232 | 2.06 | complement component 3 |
| Cartpt | 29131 | −3.09 | CART prepropeptide |
| Casq1 | 686019 | −1.87 | calsequestrin 1 (fast-twitch, skeletal muscle) |
| Casq2 | 29209 | 2.32 | calsequestrin 2 (cardiac muscle) |
| Ccl11 c | 29397 | 1.41 | chemokine (C-C motif) ligand 11 |
| Cd36 a | 29184 | 1.04 | CD36 molecule (thrombospondin receptor) |
| Cfb | 294257 | 0.65 | complement factor B |
| Cfh | 155012 | 0.76 | complement factor H |
| Chek2 a | 114212 | −0.92 | checkpoint kinase 2 |
| Cidec | 500292 | 1.65 | cell death-inducing DFFA-like effector c |
| Col1a1 | 29393 | 0.80 | collagen, type I, alpha 1 |
| Cpox | 304024 | 0.50 | coproporphyrinogen oxidase |
| Crp a d | 25419 | detected only in ISIAH rats | C-reactive protein, pentraxin-related |
| Cx3cr1 | 171056 | 0.75 | chemokine (C-X3-C motif) receptor 1 |
| Cxcl10 | 245920 | −1.90 | chemokine (C-X-C motif) ligand 10 |
| Cxcl12 | 24772 | 0.91 | chemokine (C-X-C motif) ligand 12 |
| Cyba a | 79129 | 0.68 | cytochrome b-245, alpha polypeptide |
| Cyp2e1 | 25086 | 1.91 | cytochrome P450, family 2, subfamily e, polypeptide 1 |
| Dab2 | 79128 | 0.79 | disabled homolog 2 (Drosophila) |
| Dcaf12l1 | 313296 | −1.59 | DDB1 and CUL4 associated factor 12-like 1 |
| Dcn | 29139 | 0.54 | decorin |
| Dgat1 a d | 84497 | 0.63 | diacylglycerol O-acyltransferase 1 |
| Dusp1 c | 114856 | −0.94 | dual specificity phosphatase 1 |
| Ednrb | 50672 | 0.82 | endothelin receptor type B |
| Ehhadh | 171142 | 2.01 | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase |
| Entpd5 | 314312 | −1.00 | ectonucleoside triphosphate diphosphohydrolase 5 |
| Ephx2 a b d e | 65030 | 4.37 | epoxide hydrolase 2, cytoplasmic |
| Ercc4 | 304719 | −1.12 | excision repair cross-complementing rodent repair deficiency, complementation group 4 |
| F13a1 | 60327 | 1.00 | coagulation factor XIII, A1 polypeptide |
| Fabp4 a | 79451 | 1.61 | fatty acid binding protein 4, adipocyte |
| Fam111a | 499322 | 3.85 | family with sequence similarity 111, member A |
| Fam126a | 499975 | −0.72 | family with sequence similarity 126, member A |
| Fas | 246097 | −0.80 | Fas (TNF receptor superfamily, member 6) |
| Fbn1 | 83727 | 0.69 | fibrillin 1 |
| Fgb | 24366 | detected only in ISIAH rats | fibrinogen beta chain |
| Fgg | 24367 | 1.47 | fibrinogen gamma chain |
| Fmo3 | 84493 | 0.57 | flavin containing monooxygenase 3 |
| Fn1 | 25661 | 0.76 | fibronectin 1 |
| Foxo1 a | 84482 | −0.86 | forkhead box O1 |
| Fus | 317385 | 0.65 | fused in sarcoma |
| Gabbr1 | 81657 | 1.11 | gamma-aminobutyric acid (GABA) B receptor 1 |
| Galns | 292073 | 0.81 | galactosamine (N-acetyl)-6-sulfate sulfatase |
| Gas6 | 58935 | 0.50 | growth arrest specific 6 |
| Gatm | 81660 | −1.26 | glycine amidinotransferase (L-arginine:glycine amidinotransferase) |
| Gcgr | 24953 | 1.02 | glucagon receptor |
| Gfpt2 | 360518 | 1.51 | glutamine-fructose-6-phosphate transaminase 2 |
| Gk | 79223 | −0.63 | glycerol kinase |
| Glrx | 64045 | 0.66 | glutaredoxin (thioltransferase) |
| Gria1 | 50592 | −2.39 | glutamate receptor, ionotropic, AMPA 1 |
| Gstp1 | 24426 | −0.53 | glutathione S-transferase pi 1 |
| Hap1 | 29430 | −0.61 | huntingtin-associated protein 1 |
| Hdac4 | 363287 | 0.73 | histone deacetylase 4 |
| Hmgb1 | 25459 | −0.84 | high mobility group box 1 |
| Hmgcr a b d | 25675 | 0.63 | 3-hydroxy-3-methylglutaryl-CoA reductase |
| Hmox1 a | 24451 | −0.69 | heme oxygenase (decycling) 1 |
| Hp a b c d | 24464 | 1.10 | haptoglobin |
| Hsd11b2 | 25117 | −1.47 | hydroxysteroid 11-beta dehydrogenase 2 |
| Hspa1a | 24472 | 0.70 | heat shock 70kD protein 1A |
| Hyal1 | 367166 | 0.49 | hyaluronoglucosaminidase 1 |
| Ifih1 | 499801 | 0.69 | interferon induced with helicase C domain 1 |
| Igf1 | 24482 | −2.12 | insulin-like growth factor 1 |
| Il1r1 | 25663 | 0.86 | interleukin 1 receptor, type I |
| Iscu | 288740 | −0.65 | iron-sulfur cluster scaffold homolog (E, coli) |
| Isg15 | 298693 | 0.95 | ISG15 ubiquitin-like modifier |
| Itga2 | 170921 | −1.29 | integrin, alpha 2 |
| Itgav a c | 296456 | −0.58 | integrin, alpha V |
| Jak2 c | 24514 | −0.63 | Janus kinase 2 |
| Jak3 | 25326 | −0.57 | Janus kinase 3 |
| Jam3 | 315509 | 0.58 | junctional adhesion molecule 3 |
| Kcnma1 | 83731 | 0.77 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 |
| Lcat d | 24530 | 0.97 | lecithin cholesterol acyltransferase |
| Ldlr b d e | 300438 | 0.93 | low density lipoprotein receptor |
| LOC689064 | 689064 | 2.02 | beta-globin |
| Loxl1 | 315714 | 0.50 | lysyl oxidase-like 1 |
| Lpl a d e | 24539 | 0.52 | lipoprotein lipase |
| Lrrk2 | 300160 | 1.12 | leucine-rich repeat kinase 2 |
| Lyz2 | 25211 | 0.80 | lysozyme 2 |
| Mgp | 25333 | 0.48 | matrix Gla protein |
| Mpo | 303413 | 4.46 | myeloperoxidase |
| Mpz | 24564 | 1.69 | myelin protein zero |
| Mt2A | 689415 | −1.05 | metallothionein 2A |
| Myeov2 | 681389 | −0.53 | myeloma overexpressed 2 |
| Myo5b | 25132 | −1.13 | myosin Vb |
| Ndufaf2 | 361894 | −0.85 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 2 |
| Nefh | 24587 | 1.44 | neurofilament, heavy polypeptide |
| Nefm | 24588 | −0.79 | neurofilament, medium polypeptide |
| Nr1d1 | 252917 | −0.57 | nuclear receptor subfamily 1, group D, member 1 |
| Nucb2 | 59295 | −0.64 | nucleobindin 2 |
| Oxct1 | 690163 | −0.86 | 3-oxoacid CoA transferase 1 |
| P2ry2 | 29597 | −1.31 | purinergic receptor P2Y, G-protein coupled, 2 |
| Pah | 24616 | −0.86 | phenylalanine hydroxylase |
| Pck1 c | 362282 | 3.83 | phosphoenolpyruvate carboxykinase 1 (soluble) |
| Pfkfb1 | 24638 | 1.58 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
| Phgdh | 58835 | −1.93 | phosphoglycerate dehydrogenase |
| Pik3r1 a | 25513 | 0.50 | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) |
| Pla2g7 a | 301265 | −0.97 | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) |
| Plau d | 25619 | −0.78 | plasminogen activator, urokinase |
| Plin1 | 25629 | 2.04 | perilipin 1 |
| Postn | 361945 | 1.30 | periostin, osteoblast specific factor |
| Ppard a | 25682 | 0.56 | peroxisome proliferator-activated receptor delta |
| Pparg a d | 25664 | 1.01 | peroxisome proliferator-activated receptor gamma |
| Ppt1 | 29411 | 0.48 | palmitoyl-protein thioesterase 1 |
| Prkcb a c | 25023 | 0.90 | protein kinase C, beta |
| Psmb9 | 24967 | 0.47 | proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) |
| Ptprn | 116660 | −0.75 | protein tyrosine phosphatase, receptor type, N |
| Rbp4 | 25703 | 1.83 | retinol binding protein 4, plasma |
| Retn a | 246250 | 2.26 | resistin |
| RGD1562200 | 363471 | 0.84 | patatin-like phospholipase domain-containing protein 4-like |
| RT1-Ba c | 309621 | 0.49 | RT1 class II, locus Ba |
| RT1-Da | 294269 | 0.80 | RT1 class II, locus Da |
| RT1-Db1 | 294270 | 0.91 | RT1 class II, locus Db1 |
| S100b | 25742 | −1.72 | S100 calcium binding protein B |
| Scd1 | 246074 | 2.16 | stearoyl-Coenzyme A desaturase 1 |
| Scn1b | 29686 | −0.56 | sodium channel, voltage-gated, type I, beta |
| Serpina1 a | 24648 | 0.77 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin, member 1 |
| Serpine1 a | 24617 | −2.04 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| Slc11a1 | 316519 | 0.69 | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 |
| Slc16a12 | 309525 | 0.91 | solute carrier family 16, member 12 (monocarboxylic acid transporter 12) |
| Slc4a4 | 84484 | 0.96 | solute carrier family 4, sodium bicarbonate cotransporter, member 4 |
| Slc7a7 | 83509 | −0.69 | solute carrier family 7 (amino acid transporter light chain, y%2BL system), member 7 |
| Slc8a1 | 29715 | 0.58 | solute carrier family 8 (sodium/calcium exchanger), member 1 |
| Slc9a3 | 24784 | 4.24 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 |
| Sod2 | 24787 | 0.75 | superoxide dismutase 2, mitochondrial |
| Sorbs1 a | 686098 | −0.85 | sorbin and SH3 domain containing 1 |
| Spg11 | 311372 | −0.55 | spastic paraplegia 11 (autosomal recessive) |
| Spp1 | 25353 | −0.56 | secreted phosphoprotein 1 |
| Stat5b | 25126 | −0.50 | signal transducer and activator of transcription 5B |
| Tap1 | 24811 | 0.84 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
| Thbs1 | 445442 | 0.64 | thrombospondin 1 |
| Tnc | 116640 | 1.74 | tenascin C |
| Trpc6 | 89823 | 0.85 | transient receptor potential cation channel, subfamily C, member 6 |
| Ttr | 24856 | 3.93 | transthyretin |
| Uchl5 | 360853 | −0.57 | ubiquitin carboxyl-terminal hydrolase L5 |
| Ucp1 a | 24860 | detected only in ISIAH rats | uncoupling protein 1 (mitochondrial, proton carrier) |
| Unc13a | 64829 | −1.01 | unc-13 homolog A (C, elegans) |
| Vcam1 a d | 25361 | 0.78 | vascular cell adhesion molecule 1 |
| Vip | 117064 | −1.57 | vasoactive intestinal peptide |
| Vldlr b d | 25696 | −0.61 | very low density lipoprotein receptor |
| Wfs1 | 83725 | 1.77 | Wolfram syndrome 1 homolog (human) |
| Xdh | 497811 | −0.88 | xanthine dehydrogenase |
Genes associated with: a-insulin resistance; b - hypercholesterolemia; c - hyperglycemia; d -hyperlipidemia; e - hyperlipoproteinemias; ISIAH and WAG – rat strains used in the study