Fig 5. Cancer risk predictions for the circulating miRNA signature.

Based on lymphoma literature the miRNAs are classified as tumor promoters (or OncomiRs) and tumor suppressors. Fold-change values are calculated for each miRNA comparing Smurf2^T/T (SM2) to wild-type (WT) mice. A Carcinogenic Risk Score (CRS) is calculated based on these values to determine if there is a promoted risk for cancer (positive value) or inhibitory risk for cancer (negative value). A) Cancer risk is promoted for young Smurf2^T/T mice compared to wild-type. B) Cancer risk is promoted for old Smurf2^T/T mice compared to wild-type. C) Cancer risk is inhibited for Smurf2^T/T old mice compared to Smurf2^T/T young mice. D) Cancer risk is slightly promoted for wild-type old mice compared to wild-type young mice.