Table 2. Important features of the multicenter randomized clinical trials.
1988 (%) | 1998 (%) | 2008 (%) | P Value | |
---|---|---|---|---|
PROSPECTIVE RANDOMIZED MULTI-CENTER TRIALS | N = 64 | N = 154 | N = 207 | |
Industry sponsorship | 20 (31%) | 78 (51%) | 133 (64%) | < 0.0001 |
Positive outcomes | 53 (83%) | 124 (81%) | 143 (69%) | 0.015 |
Conflict of interest | 2 (3%) | 26 (17%) | 159 (77%) | < 0.0001 |
Study Size (Median number) | 280 | 570 | 940 | p = 0.12 |