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. 2017 Jan 20;12(1):e0170056. doi: 10.1371/journal.pone.0170056

Table 2. Important features of the multicenter randomized clinical trials.

1988 (%) 1998 (%) 2008 (%) P Value
PROSPECTIVE RANDOMIZED MULTI-CENTER TRIALS N = 64 N = 154 N = 207
Industry sponsorship 20 (31%) 78 (51%) 133 (64%) < 0.0001
Positive outcomes 53 (83%) 124 (81%) 143 (69%) 0.015
Conflict of interest 2 (3%) 26 (17%) 159 (77%) < 0.0001
Study Size (Median number) 280 570 940 p = 0.12