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. 2017 Jan 20;12(1):e0169796. doi: 10.1371/journal.pone.0169796

Fig 7. The model proposed for the regulation of holocellulolytic-encoding genes in N. crassa by PAC-3.

Fig 7

Changes in the pH environment lead to activation of PAC-3, which directly or indirectly regulates transcription of cellulases and xylanases as well as the transcription factors XLR-1, CLR-1, and CLR-2 genes. The transcription factor CLR-1 regulate transcription of both xlr-1 and clr-2 genes. These transcription factors can also regulate cellulases and xylanases. XLR-1 regulate transcription of gh3-1, gh11-1, and gh43-5 genes (purple arrows); CLR-1 regulate transcription of cbh-1 and gh7-1 genes (green arrows), and CLR-2 regulate transcription of cbh-1, gh7-1, and gh11-1 genes (red arrows). (?) Missing component in regulation of cre-1 by PAC-3.