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. 2017 Jan 20;12(1):e0170054. doi: 10.1371/journal.pone.0170054

Fig 7. Model depicting the potential role of Ust and CS/DS 2-O sulfation in melanoma metastasis.

Fig 7

Ust knock-down reduces 2-O sulfation of CS/DS proteoglycans and affects Itga5 expression possibly via FgfR1. The consequence of reduced sulfation is an impaired adhesion. α5-AB: blocking antibody for α5 integrin. For additional details refer to the text.