TABLE 1.
Transmission of CWD prions to Tg(CerPrP) mice
| Inoculum | Species | Recipient | Mean ± SE incubation time in daysa |
|---|---|---|---|
| CWD pool | Mule deer | Tg(CerPrP)1536+/− | 264 ± 3 (7/7) |
| Db99 | Mule deer | Tg(CerPrP)1536+/− | 259 ± 4 (7/7) |
| D10 | Mule deer | Tg(CerPrP)1536+/− | 225 ± 1 (8/8) |
| 7378 | Elk | Tg(CerPrP)1536+/− | 235 ± 2 (8/8) |
| RML | Mouse-adapted scrapie | Tg(CerPrP)1536+/− | >385 (0/8) |
| PBS | Tg(CerPrP)1536+/− | >360 (0/8) | |
| D10 | Mule deer | Tg(CerPrP)1536+/+ | 160 ± 3 (7/7) |
| CWD pool | Mule deer | Tg(CerPrP)1534+/− | 268 ± 2 (10/10) |
| PBS | Tg(CerPrP)1534+/− | >300 (0/6) | |
| CWD pool | Mule deer | Wild-type mice | >596 (0/7) |
a
The number of mice developing clinical signs of prion disease divided by the original number of inoculated mice is shown in parentheses.