FIG. 4.

Binding of human anti-V3 MAbs to the OD1 protein. (A and B) The human MAbs tested were originally selected either with a V3_JR-CSF-fusion protein (V3-FP) or gp120_LAI (MAbs 694/98 and 1334) (A) or with V3 peptides representing the strains HIV-1_MN and HIV-1_RF (B). The curves in red represent antibodies with 50% neutralizing activity against HIV-1_SF162, and those in blue represent antibodies that achieved <50% neutralization of the same isolate (21). The curves for the negative control antibody, which is directed against the parvovirus B19 protein, are shown in green.