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. Author manuscript; available in PMC: 2017 Jan 20.
Published in final edited form as: Bone. 2009 Mar 2;44(6):1143–1150. doi: 10.1016/j.bone.2009.02.015

Fig. 3.

Fig. 3

Production of the metalloproteases (A) MMP-1, (B) MMP-9, and (C) MMP-13, and (D) the pro-inflammatory cytokine IL-6 following specific PAR-2 activation. OA subchondral bone osteoblasts (n=9–12) were incubated for 72 h in the absence (Control) or presence of PAR-2-AP at 100 and 400 μM. Data are expressed as fold of control in which the control was assigned a value of 1. P values indicate the comparison with the untreated (Control) cells using the paired Student’s t-test.