TABLE 1.
VP6- and VP7-specific naive (CD27neg) and memory (CD27pos) B cells in three adults
| Adult | No. (%) of CD19pos B cellsa
|
No. (%) of VP6-specific B cellsb
|
No. (%) of VP7-specific B cellsb
|
No. of CD27neg B cellsc reacting with:
|
No. of CD27pos B cellsc reacting with:
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|
| CD27neg | CD27pos | CD27neg | CD27pos | CD27neg | CD27pos | VP6 | VP7 | VP6 | VP7 | |
| 1 | 27,237 (45) | 33,107 (55) | 741 (65) | 397 (35) | 2 (4) | 45 (96) | 2.2 | 0.03 | 1.2 | 0.079 |
| 2 | 23,614 (29) | 57,100 (71) | 430 (57) | 323 (43) | 8 (12) | 57 (88) | 1.8 | 0.026 | 0.5 | 0.117 |
| 3 | 15,800 (28) | 40,700 (72) | 358 (59) | 246 (41) | 4 (14) | 25 (86) | 2.3 | 0.007 | 0.6 | 0.045 |
| Mean | 66,651 (34) | 130,907 (66) | 510 (61) | 322 (39) | 4 (10) | 42 (90) | 2.1 | 0.021 | 0.76 | 0.08 |
a
Number of CD27neg and CD27pos cells in 2 × 105 enriched B-cell PBMCs.
b
Number (percentage) of VP6- or VP7-reactive B lymphocytes belonging to the CD27neg naive or CD27pos memory type cells.
c
Frequency of CD27neg or CD27pos B cells reacting with VP6 or VP7 out of 102 cells.