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. 2017 Jan;56(1):69–78.

Table 2.

Total AUC (mean ± 1 SD) above baseline until ataxia for various cardiovascular parameters (heart rate [HR], bpm; blood pressure [BP], mm Hg)

	15% CO₂	30% CO₂	50% CO₂	100% CO₂	Isoflurane	Pentobarbital–phenytoin	P
Total HR^a	4632 ± 3195	3104 ± 1606^c	1476 ± 566^c	2156 ± 783^c	2851 ± 2107^c	7656 ± 2654	<0.0001
HR/s	58.4 ± 38.4^c	65.2 ± 39.6^c	46.1 ± 14.0^c	86.6 ± 23.5^c	83.3 ± 33.3^c	219.9 ± 62.2^b	<0.0001
Total SBP	1262 ± 621^b,c	1131 ± 381^b,c	853 ± 308	728 ± 167	476 ± 334	322 ± 325	<0.0001
SBP/s	16.0 ± 7.7	23.2 ± 8.5^b	27.8 ± 10.9^c	30.0 ± 7.2^c	16.2 ± 10.9	9.3 ± 8.4	<0.0001
Total DBP^a	1049 ± 517	879 ± 423	69 ± 302	54 ± 192	402 ± 255	391 ± 442	0.0133
DBP/s	13.3 ± 6.3	17.8 ± 8.8	22.7 ± 10.2	22.0 ± 7.9	13.9 ± 8.3	11.3 ± 11.3	0.0931
Total MBP^a	1131 ± 559^c	986 ± 389^c	746 ± 297	636 ± 172	449 ± 308	362 ± 387	0.0057
MBP/s	14.4 ± 6.8	20.1 ± 8.4	24.4 ± 10.2^c	26.1 ± 6.7^c	15.5 ± 10.3	10.5 ± 10.0	0.0067

DBP, diastolic blood pressure; HR, heart rate; MBP, mean blood pressure; SBP, systolic blood pressure

CO₂ data have been published previously.²

^a

Data were transformed for analysis.

^b

Value significantly different from that for isoflurane.

^c

Value significantly different from that for pentobarbital–phenytoin.