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. 2017 Jan;56(1):69–78.

Table 4.

Total AUC (mean ± 1 SD) above baseline until death for various cardiovascular parameters (heart rate [HR], bpm; blood pressure [BP], mm Hg)

15% CO2 30% CO2 50% CO2 100% CO2 Isoflurane Pentobarbital–phenytoin P
Total HRa 10,549 ± 5883 8569 ± 4060 4159 ± 1888b,c 3354 ± 1892b,c 8578 ± 3020 16,349 ± 5829 <0.0001
HR/sa 51.7 ± 7.9 54.9 ± 26.0 41.8 ± 20.0 47.8 ± 27.0 35.6 ± 13.6 49.4 ± 15.6 0.0395
Total SBPa 1862 ± 1280c 1816 ± 706c 1315 ± 702c 845 ± 319 771 ± 665 459 ± 395 0.0014
SBP/sa 9.0 ± 6.0c 11.7 ± 5.2b,c 12.7 ± 5.4b,c 11.9 ± 4.4b,c 3.1 ± 2.5 1.6 ± 1.7 <0.0001
Total DBPa 2082 ± 1527c 2091 ± 1023c 1481 ± 859c 931 ± 374 639 ± 447 556 ± 586 <0.0001
DBP/sa 10.0 ± 6.9c 13.5 ± 7.2b,c 14.2 ± 7.1b,c 13.1 ± 5.1b,c 2.5 ± 1.7 2.0 ± 2.9 <0.0001
Total MBPa 1891 ± 1339c 1874 ± 831c 1316 ± 741 851 ± 339 722 ± 544 516 ± 491 0.0034
MBP/sa 9.1 ± 6.1c 12.1 ± 5.9b,c 12.7 ± 5.9b,c 12.0 ± 4.6b,c 2.9 ± 2.0 1.8 ± 2.3 <0.0001

DBP, diastolic blood pressure; HR, heart rate; MBP, mean blood pressure; SBP, systolic blood pressure

CO2 data have been published previously.2

a

Data were transformed for analysis.

b

Value significantly different from that for isoflurane.

c

Value significantly different from that for pentobarbital–phenytoin.