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Immunohistochemical analysis of Ki-67 in esophageal adenocarcinoma and precancerous lesions. A, Squamous mucosa. B, Columnar cell metaplasia. C, Barrett's esophagus. D, Low-grade dysplasia. E, High-grade dysplasia. F, Esophageal adenocarcinoma. In normal mucosa and non-dysplastic lesions, Ki-67 nuclear staining is distributed in the basal layer of the epithelium and lower part of the glands. In dysplastic and cancerous lesions, the glands have full thickness staining for Ki-67.
