Table 3.

Summary of p53 immunohistochemical staining in biliary hamartoma, bile duct adenoma, parenchymal extinction, and intrahepatic cholangiocarcinoma

	n	Average (% cells; any staining)	Range (% cells; any staining)	vs WD CC (P)	Average (% cells; strong staining)	Range (%; strong staining)	vs WD CC (P)	% of cases >1% strong staining
Biliary hamartoma	14	1.2	0–6.1	.001	0.0	0–0.3	.011	0.0
Biliary adenoma	21	4.7	0–14.3	.02	0.0	0.00	.002	0.0
Parenchymal extinction	11	2.3	0–15	.011	0.0	0.00	.024	0.0
All benign lesions	46	3.1	0–15	<.001	0.0	0–0.3	<.001	0.0
WD cholangiocarcinoma	16	11.5	0.2–40	n/a	0.8	0–3.9	n/a	37.5
MD/PD cholangiocarcinoma	10	19.5	0.5–69.9	.2	1.6	0–10.5	.36	30.0
All cholangiocarcinomas	26	14.6	0.2–69.9	.48	1.1	0–10.5	.62	34.6

Abbreviations: n/a, not applicable; WD, well-differentiated; CC, cholangiocarcinoma; MD/PD, moderately/poorly differentiated cholangiocarcinomas.