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Mean (± SE) body weights of groups of 18 male C57BL/6J mice fed for 9 weeks plain chow or chow with 0.25% sucralose, or plain high-fat diet, or high-fat diet with 0.25% sucralose. Both groups fed high-fat diet weighed significantly more than did those fed chow; the mice fed sucralose in high-fat diet weighed significantly less than those fed the plain high-fat diet.
