TABLE 2.

Effect of mutation in the catalytic pocket of Δ21 on the incorporation of NTPi analogs

Protein	Without Mn2+							With Mn2+
	GTP	dGTP	GDP	GMP	G	GU	GUAUA	GTP	dGTP	GDP	GMP	G	GU	GUAU
Δ21	100	5	62	139	6	2,480	6,630	100	90	288	306	48	537	102
R158A	0	0	0	0	0	1	13	18	3	19	5	0	144	154
S367A	51	1	30	68	1	978	5,751	85	98	292	285	25	381	71
R386A	0	0	0	0	0	5,207	444	68	2	175	160	139	1,044	39
R394A	0	0	0	0	0	2,253	226	51	6	283	399	125	767	32
R48A	0	0	0	0	0	0	1,140	60	12	150	66	3	349	250
D225A	0	0	0	0	0	0	2,810	272	26	226	198	8	755	480