Table 2.

Braak scores and pathology counts for each subject group. Median and interquartile range of Braak staging score and neuritic plaque (NP) and neurofibrillary tangle (NFT) counts in three brain regions were compared to NC subjects. To determine significant differences between the pathology groups and NC, omnibus significance was tested using ANOVA on Ranks, with post-hoc analysis testing using Dunn’s analysis compared to NC (*p < 0.05). HPG – hippocampus/parahippocampal gyrus, IPL – inferior parietal lobe, SMTG – superior and middle temporal gyrus.

	NC	PCAD	MCI	LOAD	FTLD/DLB
Pathology Burden
Braak Stage	II [0-II]	IV* [III-V]	III* [II-V]	VI* [V-VI]	II [0-III]
NP – HPG	0	0 [0–1]	0.3 [0–5.0]	2.8* [0.9–4.1]	0 [0–0.8]
NP – SMTG	0 [0–5.0]	10.3 [7.5–19.5]	5.6 [2.3–12.4]	16.4* [6.1–30.8]	3.4 [0–17.8]
NP – IPL	0 [0–7.2]	13.1 [7.4–31.4]	6 [2–14.3]	19.8* [8.6–30.9]	5.8 [1.6–13.2]
NFT – HPG	3.2 [0.7–6.8]	2.6 [0.6–8.9]	24.3 [2.3–78.9]	20.7 [10.6–50.8]	1.8 [0–4]
NFT – SMTG	0	0.7 [0.1–1.5]	1.2 [0.5–9.4]	18.2* [11.0–24.6]	0 [0–0.8]
NFT – IPL	0	0.5 [0.2–1.3]	0 [0–5.8]	15.1* [9.6–25.6]	0 [0–0.4]