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. Author manuscript; available in PMC: 2018 Jan 20.
Published in final edited form as: ACS Chem Biol. 2016 Dec 13;12(1):234–243. doi: 10.1021/acschembio.6b00855

Figure 5. Patient serum IgG binding profiles.

Figure 5

Each hit ligand's serum IgG binding was evaluated for individual patient serum samples classified as TB negative control, latent TB, or active TB. Samples of each classification were either a component of “discovery” serum pools used for library screening or additional “test” samples. The binding behavior of each serum sample is displayed as side-by-side color-coded bars. The left bar indicates whether IgG binding exceeded the statistical significance threshold for the ligand, the right bar indicates the fraction of serum IgG bound in the presence of soluble ligand as the competitor (10 μM).