Table 5.

Multivariate models predicting failure to achieve primary fascial closure during admission (OR: odds ratio, CI: confidence interval, NPWT: negative pressure wound therapy, PRBC: packed red blood cell transfusion, FFP: fresh frozen plasma transfusion). Trauma model: AUROC (95% CI) = 0.864 (0.763-0.966); Hosmer and Lemeshow significance = 0.703. Sepsis model: AUROC (95% CI) = 0.718 (0.624-0.812); Hosmer and Lemeshow significance = 0.792.

Population Factors	OR	95% CI	p
Trauma
≥2.5 L NPWT output at 48 hours	5.7	1.3-24.4	0.020
≥10 L crystalloid infusion at 48 hours	5.1	1.1-23.6	0.036
≥10 U PRBC+FFP at 48 hours	4.9	1.0-23.6	0.049
Sepsis
Relaparotomy within 48 hours	0.2	0.0-0.6	0.009
≥3 diagnostic/therapeutic laparotomies	2.2	1.4-3.3	<0.001