1.

Correlations of Bcl-2 immunohistochemical density of tissue microarrays and age specific groups with clinicopathological features of HCC patients (n = 374)

Variable	Bcl-2 density		P	Age specific groups			P
	Low (n = 153)	High (n = 153)		22-44 y (n = 84)	45-60 y (n = 159)	61-76 y (n = 63)
ALT, alanine aminotransferase; BCLC, Barcelona Clinic Liver Cancer staging system; HBsAg, hepatitis B surface antigen; χ2-tests were conducted for all analyses.
Age, years
≤44	43	41	0.888
45-60	81	78
≥61	29	32
Preoperative AFP (ng/mL)							0.150
≤20	64	58	0.484	28	63	31
>20	89	95		56	96	32
HBsAg							<0.0001
Negative	9	13	0.784	2	6	14
Positive	144	140		82	153	49
Liver cirrhosis							0.012
No	14	21	0.209	15	10	10
Yes	139	132		69	149	53
ALT (U/L)							0.965
≤75	130	138	0.166	73	140	55
>75	23	15		11	19	8
Tumor size (cm)							0.723
≤5	116	119	0.685	65	124	46
>5	37	34		19	35	17
Tumor encapsulation							0.200
None	80	77	0.732	37	83	37
Complete	73	76		47	76	26
Vascular invasion							0.824
No	99	106	0.395	54	108	43
Yes	54	47		30	51	20
BCLC stage							0.995
0/A	83	86	0.730	46	88	35
B/C	70	67		38	71	28
Tumor differentiation							0.378
I-II	123	106	0.025	53	126	50
III-IV	30	47		31	33	13