2.

Univariate analyses of factors associated with OS and TTR

Variable	OS			TTR
	Hazard ratio (95% CI)	P		Hazard ratio (95% CI)	P
95% CI, 95% confidence interval; AFP, alpha-fetoprotein; NS, not significant (Cox proportional hazards regression model); BCLC, Barcelona Clinic Liver Cancer Staging System.
Age, years (> 52 vs. ≤ 52)	0.531 (0.723-1.875)	0.531		1.122 (0.683-1.842)	0.650
HBsAg (positive vs. negative)	2.554 (0.929-7.021)	0.069		3.187 (0.997-10.182)	0.051
AFP (ng/mL; > 20 vs. ≤ 20)	1.717 (1.033-2.856)	0.037		1.539 (0.916-2.585)	0.104
Liver cirrhosis (yes vs. no)	1.211 (0.619-2.371)	0.576		1.693 (0.770-3.722)	0.190
ALT (U/L; > 75 vs. ≤ 75)	1.964 (1.072-3.597)	0.029		1.668 (0.848-3.282)	0.138
Tumor size (cm; > 5 vs. ≤ 5)	2.198 (1.328-3.639)	0.002		1.927 ( 1.120-3.318)	0.018
Tumor number (multiple vs. single)	2.915 (1.057-8.042)	0.039		1.273 (0.310-5.221)	0.738
Vascular invasion (yes vs. no)	2.435 (1.509-3.931)	<0.001		1.915 (1.153-3.182)	0.012
BCLC stage (B/C vs. A)	2.046 (1.096-3.821)	0.025		1.767 (0.958-3.261)	0.068
Tumor differentiation (III-IV vs. I-II)	1.440 (0.871-2.381)	0.156		1.533 (0.912-2.577)	0.107
Tumor encapsulation (none vs. complete)	1.419 (0.880-2.287)	0.151		1.278 (0.779-2.096)	0.331
Bcl-2 (high vs. low)	0.403 (0.245-0.665)	<0.001		0.368 (0.219-0.618)	<0.001