3.

Multivariate analyses of factors associated with OS and TTR

Variable	OS			TTR
	Hazard ratio (95% CI)	P		Hazard ratio (95% CI)	P
95% CI, 95% confidence interval; AFP, alpha-fetoprotein; NS, not significant (Cox proportional hazards regression model).
AFP (ng/mL; > 20 vs. ≤ 20)	1.333 (0.785-2.265)	0.035
ALT (U/L; > 75 vs. ≤ 75)	1.960 (1.059-3.629)	0.287
Tumor size (cm; > 5 vs. ≤ 5)	1.687 (1.007-2.825)	0.047		1.667 (0.959-2.897)	0.070
Tumor number (multiple vs. single)	1.585 (0.557-4.506)	0.388
Vascular invasion (yes vs. no)	2.033 (1.230-3.359)	0.006		1.664 (0.991-2.792)	0.054
Bcl-2 (high vs. low)	0.458 (0.275-0.761)	0.003		0.391 (0.232-0.659)	<0.001