Skip to main content
. 2016 Sep 23;37(12):15371–15381. doi: 10.1007/s13277-016-5406-2

Fig. 1.

Fig. 1

Domain structure of HBx with some possible functions. WT wild type. The functional domains of 154-aa HBx protein shown include the transpression domain (aa 1–20), the signal transduction domain (aa 58–119), the transactivation domain (aa 58–140), and the nuclear transactivation domain (aa120–140). Nine conserved cysteine residues that have proven to be crucial for HBx’s various functions are indicated by the arrows (aa 7, 17, 61, 69, 78, 115, 137, 143, and 148) [47]. HBx domains for interaction with various transcription factors such as TFIIB (aa 51–148), RPB5 (aa 51–136), TBP (aa 110–143), P53 (aa 102–136), etc. are shown [4850]