Table 2.
Parameter/ criteria [n (%)] | Placebo n = 9 | Regadenoson | ||
---|---|---|---|---|
100 μg n = 9 | 200 μg n = 8 | 400 μg n = 8 | ||
Systolic blood pressure | ||||
<90 mm Hg | 0 | 3 (33.3) | 0 | 0 |
≥200 mm Hg | 0 | 0 | 0 | 0 |
Decrease >35 mm Hg | 0 | 2 (22.2) | 1 (12.5) | 0 |
Increase ≥115 mm Hg | 0 | 0 | 0 | 0 |
≥80 and increase ≥20 mm Hg | 0 | 0 | 0 | 0 |
Diastolic blood pressure | ||||
<50 mm Hg | 0 | 1 (11.1) | 0 | 1 (12.5) |
≥115 mm Hg | 0 | 0 | 0 | 0 |
Decrease >25 mm Hg | 0 | 1 (11.1) | 1 (12.5) | 0 |
Increase ≥30 mm Hg | 0 | 0 | 0 | 0 |
Heart rate | ||||
≥100 bpm | 0 | 3 (33.3) | 7 (87.5) | 6 (75.0) |
Increase >40 bpm | 0 | 2 (22.2) | 4 (50.0) | 7 (87.5) |
All data from the pharmacodynamic population