. 2016 Sep 23;21(1):31–43. doi: 10.1007/s40291-016-0234-z

Table 4.

MiRNAs manipulated prior to insult in AMD animal model

miRNA	Delivery	Compound	Model	Effect^b	Source
mmu-miR-126^a	Intravitreal injection	miR-mimic	OIR	↓ Retinal NV	[114]
mmu-miR-128^a	Intravitreal injection	miR-mimic	OIR	↓ Retinal NV	[105]
mmu-miR-132^a	Intraocular injection	anti-miR	OIR	↓ NV	[106]
mmu-miR-150^a	Intraocular injection	pre-miR	OIR	↓ Retinal NV	[90]
	Intraocular injection	pre-miR	Laser induced CNV	↓ Choroidal NV	[90]
	Intravitreal injection	miR-mimic	OIR	↓ Retinal NV	[108]
	Knockout mice	miR-150-/-	Laser induced CNV	↑ Choroidal NV	[108]
mmu-miR-155^a	Knockout mice	miR-155-/-	OIR	↑ Retinal NV	[75]
	Knockout mice	miR-155-/-	Retinal development	↓ Vascular area	[75]
	Intravitreal injection	miR-mimic	Retinal development	↓ Vascular area	[75]
mmu-miR-184^a	Intraocular injection	pre-miR	OIR	↓ Retinal NV	[90]
mmu-miR-23/27^a	Intravitreal injection	anti-miR	Laser induced CNV	↓ Choroidal NV	[107]
mmu-miR-24^a	Subretinal	miR-mimic	Laser induced CNV	↓ Choroidal NV	[109]
mmu-miR-31^a	Intraocular injection	pre-miR	OIR	↓ Retinal NV	[90]
mmu-miR-31^a	Intraocular injection	pre-miR	Laser induced CNV	↓ Choroidal NV	[90]

OIR oxygen-induced retinopathy, CNV choroidal neovascularization, AMD age-related macular degeneration, miRNA micro RNA

^aMature miRNA strand unknown/not mentioned

^bA “↓” indicates a decrease and a “↑” indicates an increase in the respective phenotype