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. 2016 Oct 10;37(12):15783–15793. doi: 10.1007/s13277-016-5374-6

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — ARHGDIA downregulation promotes cell proliferation in vitro. a ARHGDIA expression in different human glioma cell lines. b–d The interference effect of three siRNAs in H4, U251, and U87 cells. e–f ARHGDIA knockdown in H4 (e) or U251 cells (f) by siRNA1 treatment for 48 h promotes cell proliferation by decreasing proportion of G2/M-phase cells (*p < 0.05). siControl: nontargeting control siRNA. g The overexpression of ARHGDIA in U87 cells with transfection of pHA-ARHGDIA plasmids for 48 h inhibits cell proliferation by increasing the proportion of G2/M-phase cells (*p < 0.05)