Fig. 7.

Schematic diagram summary of ARHGDIA effects on tumor progression in human gliomas. Under normal physiological conditions, ARHGDIA inhibits activation of Rho proteins by maintaining the GDP-bound Rho proteins in cytosol (a). When ARHGDIA protein is downregulated in glioma, the GTP-form Rho GTPases are activated (b) and subsequently Akt phosphorylaton is elevated, which promotes cell proliferation, cell cycle, and cell migration