Fig. 1.

Distribution of demyelinating lesions in MS and different EAE-based models. The sites of demyelinated lesions were shown in camera lucida drawings of human brain sections, were projected into schemes redrawn after Paxinos and Watson [124] for rat and murine brain sections, or were outlined in optic nerve and spinal cord schemes. Areas of primary demyelination are shown in green, lesions with dominant axonal loss, and secondarily demyelinated areas in blue, and cortical demyelination in brown. Shaded schemes indicate lack of sufficient information for lesion distribution