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. 2017 Jan 1;7(1):41–52.

Figure 3.

Figure 3

Sildenafil inhibits colonic tumorigenesis dependent on inflammation existence. (A) Schema of AOM treatment and Sildenafil injection. (B) ELISA analysis of PDE-5 expression in colonic tissues from Sildenafil and normal saline (NS) treatment mice (n=5). (C) Representative macroscopic findings of colon tumors induced by AOM in Sildenafil and normal saline (NS) treatment mice. (D, E) Number of macroscopic tumors (D) and tumor burden of AOM-treated mice (E) per colon (n=6). (F) Colon length of AOM/DSS-treated mice per colon (n=6). (G, H) H&E staining of colonic tissue after AOM treatment (G). Scale bar=200 μm. Tumor area (%, tumor area/total area) was calculated (H, n=3).