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. 2017 Jan 1;7(1):41–52.

Figure 4.

Figure 4

Inhibition of PDE-5 prevents colon from DSS-induced inflammation. (A) Schema of DSS treatment and Sildenafil injection. (B) ELISA analysis of PDE-5 expression in colonic tissues from Sildenafil and normal saline (NS) treatment mice (n=5). (C) Representative macroscopic findings ofcolon tumors induced by DSS in Sildenafil and normal saline (NS) treatment mice. (D) Colon length of DSS-treated mice per colon (n=6). (E, F) Hemoccult (E) and stool consistency analysis of DSS-treated mice (F) per colon (n=6). (G, H) H&E staining ofcolonic tissue after DSS treatment (G). Scale bar=200 μm. Histologic score was calculated (H, n=3). (I) ELISA analysis of inflammation-related cytokine expression in colonic tissue from DSS-treated mice (n=3).