Table 4.
Clinicopathological associations based on germline mutation status
| 194 patients informative for germline mutations | |||
|
| |||
| Germline negative, N=144 | Germline positive, N=50 | P value | |
|
| |||
| Menopausal status | <0.001* | ||
| Post | 86 (59.31%) | 13 (26.00%) | |
| Pre | 59 (40.69%) | 37 (74.00%) | |
| Histological grade | 0.015* | ||
| I or II | 26 (17.93%) | 2 (4.00%) | |
| III | 119 (82.07%) | 48 (96.00%) | |
| Age (yrs) | <0.001^ | ||
| N patients | 144 | 50 | |
| Mean ± SD | 53.7±12.5 | 44.6±10.3 | |
| Median | 54.5 | 43.5 | |
| TILs density | 0.007^ | ||
| N patients | 140 | 48 | |
| Mean ± SD | 20.5±20.7 | 27.8±21.2 | |
| Median | 10 | 24 | |
|
| |||
| 50 patients with germline mutations | |||
|
| |||
| BRCA1 | Non-BRCA1 | ||
|
| |||
| TNBC central | 0.017* | ||
| NO | 5 (12.82%) | 5 (45.45%) | |
| YES | 34 (87.18%) | 6 (54.55%) | |
| Menopausal status | 0.014* | ||
| Post | 7 (17.95%) | 6 (54.55%) | |
| Pre | 32 (82.05%) | 5 (45.45%) | |
| Positive nodes | <0.001* | ||
| ≥4 | 4 (10.26%) | 7 (63.64%) | |
| 0 to 3 | 35 (89.74%) | 4 (36.36%) | |
| Age (yrs) | 0.020^ | ||
| N patients | 39 | 11 | |
| Mean ± SD | 42.3±8.4 | 52.5±12.5 | |
| Median | 42 | 56 | |
*
Pearson’s chi sq;
^
Non-parametric.