Table 6.
Univariate Cox analysis results for DFS
| Variable | Total N | N patients | N events | HR | 95% CI low | 95% CI high | P value |
|---|---|---|---|---|---|---|---|
| Age ≥50 vs. <50) | 194 | 105 vs. 89 | 27 vs. 27 | 0.777 | 0.456 | 1.326 | 0.355 |
| Menopausal (post vs. pre) | 194 | 99 vs. 95 | 24 vs. 30 | 0.740 | 0.432 | 1.265 | 0.271 |
| Tumor size (>2 vs. ≤2) | 192 | 116 vs. 76 | 37 vs. 16 | 1.833 | 1.018 | 3.298 | 0.043 |
| Number of positive nodes (≥4 vs. 0-3) | 190 | 44 vs. 146 | 21 vs. 31 | 2.735 | 1.570 | 4.764 | <0.001 |
| Adjuvant Radiotherapy (yes vs. no) | 194 | 140 vs. 54 | 35 vs. 19 | 0.657 | 0.376 | 1.150 | 0.141 |
| TILs (continuous, 10% increments) | 188 | 0.805 | 0.678 | 0.956 | 0.013 | ||
| Germline (positive vs. negative) | 194 | 50 vs. 144 | 11 vs. 43 | 0.802 | 0.413 | 1.557 | 0.515 |
| Tumor mutation (any vs. none) | 191 | 136 vs. 55 | 43 vs. 11 | 1.722 | 0.888 | 3.340 | 0.108 |
| TP53 (MUT vs. nonMUT) | 191 | 113 vs. 78 | 33 vs. 21 | 1.133 | 0.655 | 1.958 | 0.656 |
| Germilne* TP53 MUT status# | 191 | 0.027^ | |||||
| Germline positive, TP53 MUT vs. TP53 WT | 47 | 25 vs. 22 | 9 vs. 2 | 4.121 | 0.882 | 19.250 | |
| Germline negative, TP53 MUT vs. TP53 WT | 144 | 88 vs. 56 | 24 vs. 19 | 0.827 | 0.453 | 1.510 |
Notes: HR: Hazard ratio;
#
Interaction between germline status and tumor TP53 mutations;
^
Likelihood ratio test for interaction;
*
Interaction (statistical);
WT: Wild-type; Significant results are shown in bold.