Table 7.

Multivariate analysis results for DFS

Multivariate Model (all pts: 180)	N patients	N events	HR	95% CI low	95% CI high	p-value
Germline (positive vs. negative)	45 vs. 135	11 vs. 37	0.514	0.115	2.301	0.384
TP53 (MUT vs. nonMUT)	106 vs. 74	29 vs. 19	0.821	0.426	1.581	0.555
Germline* TP53 MUT status#						0.053^
Germline positive; TP53 MUT vs. WT	24 vs. 21	9 vs. 2	3.34	0.615	18.125
Germline negative; TP53 MUT vs. WT	82 vs. 53	20 vs. 17	0.847	0.439	1.636
Menopausal status (post vs. pre)	89 vs. 91	20 vs. 28	0.694	0.379	1.272	0.238
Tumor size (>2 vs. ≤2)	107 vs. 73	34 vs. 14	1.465	0.756	2.839	0.257
Number of positive nodes (≥4 vs. 0-3)	41 vs. 139	20 vs. 28	3.78	1.999	7.145	<0.001
Adjuvant Radiotherapy (yes vs. no)	134 vs. 46	31 vs. 17	0.486	0.257	0.918	0.026
TILs (continuous, 10% increments)	n.a.	n.a.	0.769	0.624	0.948	0.014

^#Interaction between germline status and tumor TP53 mutations;

^{^}Likelihood ratio test for interaction;

^*Interaction (statistical);

HR: Hazard ratio; N.a.: Not applicable for continuous variables; Significant results are shown in bold.