Figure 2.

Nicousamide ameliorated the glomerulosclerosis in diabetic rats dose dependently. A. Representations of PAS-stained kidneys of normal rats, diabetes model rats and nicousamide-treated diabetes rats (×200). As shown in DN model group, severe sclerosis in glomerulus segments, segmental and diffuse mesangial expansion of the glomeruli, and tubule vacuolar degeneration in proximal tubules had been observed, while nicousamide treatment could effectively ameliorate these pathological injuries. B. Glomerulosclerosis quantification, #P<0.05, ##P<0.01 vs. normal group; *P<0.05, **P<0.01 vs. diabetic nephropathy model group.