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. 2017 Jan 15;9(1):126–135.

Figure 5.

Figure 5

MiR-221 inhibits osteogenic differentiation of C2C12 cells by targeting RUNX2. A. Dynamic changes of RUNX2 protein levels in BMP-2-induced C2C12 cells. The protein samples from Figure 1C were determined by Western blot assays. *P < 0.05. B. The expressions of OC in C2C12 cells transfected with miR-221 control, inhibitor or miR-221 inhibitor + RUNX2 inhibitor detected by RT-qPCR. *P < 0.05. C. The expressions of ALP in C2C12 cells transfected with miR-221 control, inhibitor or miR-221 inhibitor + RUNX2 inhibitor detected by RT-qPCR. *P < 0.05. D. The expressions of COL1A1 in C2C12 cells transfected with miR-221 control, inhibitor or miR-221 inhibitor + RUNX2 inhibitor detected by RT-qPCR. *P < 0.05.