FIG. 1.

Granzymes A and B have functionally redundant roles in regulating γHV68 early latent infection. Peritoneal cells from infected GzmA^−/−, GzmB^−/−, GzmAXB^−/−, and 129/SvJ mice were analyzed for the frequency of cells which reactivated virus ex vivo and which harbored viral genome at 16 (A) or 42 (B) dpi. No preformed infectious virus was detected in mechanically disrupted samples (data not shown). Number of independent experiments: GzmA^−/−, three; GzmB^−/−, four; GzmAXB^−/−, four; 129/SvJ, seven.