FIG. 2.

Orphan granzymes in the GzmB locus regulated γHV68 latent infection at the early time point. Peritoneal cells from infected mice were analyzed for the frequency of cells which reactivated virus ex vivo and which harbored viral genome at 16 dpi. (A) Comparison of GzmB-cluster^−/−, GzmB^−/−, and 129/SvJ mice. (B) Comparison of GzmAXB-cluster^−/−, GzmAXB^−/−, and 129/SvJ mice. No preformed infectious virus was detected in mechanically disrupted samples (data not shown). Number of independent experiments: GzmB-cluster^−/−, five; GzmB^−/−, four; GzmAXB-cluster^−/−, five; GzmAXB^−/−, four; 129/SvJ, seven.