FIG. 3.

Orphan granzymes, but not granzymes A and B, regulated γHV68 latent infection at the late time point. Peritoneal cells from infected GzmAXB^−/−, GzmB-cluster^−/−, GzmAXB-cluster^−/−, and 129/SvJ mice were analyzed at 42 dpi for the frequency of cells which reactivated virus ex vivo (A) or cells which harbored viral genome (B). No preformed infectious virus was detected in mechanically disrupted samples (data not shown). Number of independent experiments: GzmB-cluster^−/−, five; GzmAXB-cluster^−/−, four; GzmAXB^−/−, four; 129/SvJ, eight.