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Impaired regulation of latent infection in granzyme-deficient mice is not due to uncontrolled lytic replication during acute infection. Titers in spleens from infected GzmAXB−/−, GzmB-cluster−/−, GzmAXB-cluster−/−, and 129/SvJ mice were determined by plaque assay at 4 (A) or 9 (B) dpi. The limit of detection is indicated by the horizontal line. The number of mice analyzed is given above each bar.
