Table 5.

Association between PM₁₀ exposures, singles methylation genes and genes grouped by common inflammatory pathway.

Exposure to PM10 before recruitment	β-coefficienta (SE), p-values
	CD14		TLR4	TNF-α			Inflammatory pathway: CD14, TLR4, TNF-αb
1 day	−0.030 (0.056)	0.591	−0.156 (0.088)	0.080	0.015 (0.035)	0.673	−0.002 (0.032)	0.942
2 days	−0.061 (0.055)	0.269	0.048 (0.083)	0.570	0.002 (0.035)	0.957	0.007 (0.032)	0.833
3 days	−0.091 (0.054)	0.093	0.041 (0.078)	0.599	0.015 (0.034)	0.670	−0.006 (0.032)	0.848
4 days	−0.120 (0.054)	0.029	−0.017 (0.085)	0.839	−0.034 (0.035)	0.327	−0.052 (0.032)	0.109
5 days	−0.120 (0.054)	0.028	0.011 (0.096)	0.905	−0.047 (0.035)	0.180	−0.047 (0.032)	0.149
6 days	−0.155 (0.056)	0.006	−0.169 (0.084)	0.048	−0.011 (0.036)	0.768	−0.075 (0.032)	0.019
7 days	−0.041 (0.055)	0.453	−0.260 (0.093)	0.006	−0.004 (0.036)	0.918	−0.035 (0.032)	0.279
8 days	0.047 (0.055)	0.400	−0.187 (0.098)	0.059	−0.005 (0.036)	0.902	0.014 (0.033)	0.677
9 days	0.018 (0.054)	0.741	−0.060 (0.091)	0.511	0.017 (0.036)	0.640	0.018 (0.033)	0.580
10 days	0.051 (0.056)	0.365	0.012 (0.088)	0.890	−0.011 (0.037)	0.768	0.043 (0.034)	0.204
11 days	0.002 (0.056)	0.972	−0.020 (0.075)	0.787	0.015 (0.035)	0.671	0.011 (0.032)	0.726
12 days	−0.032 (0.057)	0.574	−0.077 (0.079)	0.332	0.019 (0.036)	0.590	−0.011 (0.033)	0.726
13 days	−0.053 (0.059)	0.367	−0.003 (0.102)	0.975	0.016 (0.037)	0.666	−0.005 (0.034)	0.893
14 days	−0.083 (0.057)	0.146	−0.007 (0.108)	0.952	−0.014 (0.036)	0.703	−0.015 (0.034)	0.657

^aBeta coefficients expressing the logarithmic change in DNA methylation associated with a standard deviation change in PM₁₀ level. Models adjusted for: body mass index, age, sex, percentage of neutrophils, smoking habits, position, run, batch, interaction terms among position, run and batch.

^bAlso adjusted for singles methylation genes.