Table 6.
Association of PM10 exposure, the sixth days before recruitment, with singles methylation genes/inflammatory system pathway, using a quartile model approach.
| Methylation geneb | β-coefficient (SE)a |
|||
|---|---|---|---|---|
| Quartile 2 | Quartile 3 | Quartile 4 | p-valuec | |
| Exposure to PM10 6 days before | ||||
| CD14 | 0.047 (0.145) | −0.288 (0.153) | −0.441 (0.152) | 0.003 |
| TLR4 | 0.065 (0.181) | 0.063 (0.222) | −0.300 (0.231) | 0.410 |
| TNF-α | 0.027 (0.094) | 0.128 (0.1) | −0.017 (0.099) | 0.465 |
| Inflammatory pathway: | 0.098 (0.084) | −0.048 (0.09) | −0.168 (0.089) | 0.023 |
| CD14, TLR4, TNF-αd | ||||
a
Beta coefficients expressing the logarithmic change in DNA methylation Z-scores associated with change in PM10 switching from the first quartile to the others.
b
Adjusted for: body mass index, age, sex, percentage of neutrophils, smoking habits, position, run, batch, interaction terms among positions, run and batch.
c
Also adjusted for single methylation genes.
d
The type 3 test of fixed effects, testing whether there is any difference among the 4 group. Quartile 1 is the referent group.