TABLE 1.
Inhibition of influenza virus infection in HTBE and human nasal epithelial cell cultures by OC
| Virus | Culture | MOIa | Mean (SD) no. of infected cells/epithelial segment
|
Control/treated ratio | Pb | |
|---|---|---|---|---|---|---|
| Control | Drug treated | |||||
| A/Memphis/14/96 (HINI) | HTBE | 0.07 | 560 (60) | 26 (6) | 22 | <0.0001 |
| HTBE | 0.25 | 3,100 (600) | 48 (20) | 65 | <0.0001 | |
| HNE | 0.25 | 230 (80) | 2.0 (1.3) | 120 | <0.0001 | |
| A/Duck/Alberta/119/98 (HINI) | HTBE | 0.08 | 2,800 (200) | 44 (15) | 64 | <0.0001 |
| HTBE | 0.04 | 1,500 (300) | 36 (13) | 42 | <0.0001 | |
| HNE | 0.04 | 260 (90) | 0.50 (0.53) | 520 | <0.0001 | |
| A/Turkey/Italy/2379/99 (H7NI) | HTBE | 0.25 | 1,500 (200) | 30 (12) | 50 | <0.0001 |
| A/Chicken/Germany/R28/03 (H7N7) | HTBE | 0.002 | 36 (16) | 0.25 (0.46)c | 140 | <0.0001 |
| 0.88 (0.64)d | 40 | <0.0001 | ||||
| A/Sydney/5/97-like (H3N2) | HTBE | 0.3 | 222 (22) | 4.8 (1.8) | 47 | <0.0001 |
| 154 (39)e | 1.5 | 0.007 | ||||
| 210 (35)f | 1.1 | 0.42 | ||||
| A/Sydney/5/97-like (H3N2) (drug-resistant NA mutant) | HTBE | 0.35 | 360 (93) | 270 (52) | 1.3 | 0.017 |
a
MOI, multiplicity of infection calculated on the basis of virus infectivity determined in MDCK cells.
b
P value for comparison between drug-treated and control cultures (unpaired t test).
c
Infection in the presence of 1 μM OC.
d
Infection in the presence of 0.1 μM OC.
e
OC was added to the culture 1 h after virus inoculation.
f
OC was added to the culture 4 h after virus inoculation.