TABLE 2.
Detection of viral RNA by RT-PCR from blood and pharyngeal swabs.
| Ferret no. | Immunogen | Presence of viral RNAa on indicated days in:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood
|
Pharyngeal swabs
|
||||||||||||
| 1-3 | 4-6 | 8-10 | 13-15 | 20-22 | 27-29 | 1-3 | 4-6 | 8-10 | 13-15 | 20-22 | 27-29 | ||
| 1 | MVA | − | − | + | − | + | − | + | − | + | − | − | − |
| 2 | MVA | − | − | − | − | + | − | + | + | + | − | − | − |
| 3 | MVA | − | − | − | + | − | − | + | + | − | − | − | − |
| 7 | rMVA-S | − | − | + | + | − | − | + | + | + | − | − | − |
| 8 | rMVA-S | − | − | + | + | + | − | + | + | + | + | + | − |
| 9 | rMVA-S | − | − | − | + | − | − | + | + | + | − | − | − |
| 10 | PBS | − | − | + | + | − | − | + | + | − | − | − | − |
| 11 | PBS | − | − | − | + | + | − | + | + | + | + | − | − |
| 12 | PBS | − | − | − | − | − | − | + | + | + | − | − | − |
a
Due to the limited working capacity in a biosafety level 4 space, only one ferret from a group could be manipulated for blood and pharyngeal swab collection on a particular day after SARS-CoV challenge. +, RT-PCR positive; −, RT-PCR negative.