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. 1991 Oct 1;88(19):8372–8376. doi: 10.1073/pnas.88.19.8372

31P saturation transfer and phosphocreatine imaging in the monkey brain.

B Mora 1, P T Narasimhan 1, B D Ross 1, J Allman 1, P B Barker 1
PMCID: PMC52510  PMID: 1924297

Abstract

31P magnetic resonance imaging with chemical-shift discrimination by selective excitation has been employed to determine the phosphocreatine (PCr) distribution in the brains of three juvenile macaque monkeys. PCr images were also obtained while saturating the resonance of the gamma-phosphate of ATP, which allowed the investigation of the chemical exchange between PCr and the gamma-phosphate of ATP catalyzed by creatine kinase. Superposition of the PCr images over the proton image of the same monkey brain revealed topological variations in the distribution of PCr and creatine kinase activity. PCr images were also obtained with and without visual stimulation. In two out of four experiments, an apparently localized decrease in PCr concentration was noted in visual cortex upon visual stimulation. This result is interpreted in terms of a possible role for the local ADP concentration in stimulating the accompanying metabolic response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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