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. 2017 Jan 21;17:67. doi: 10.1186/s12885-017-3046-6

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Antiproliferative effect of HDAC inhibitors AR-42 and SAHA on human and canine osteosarcoma cells. a, b Dose-dependent effects of AR-42 on cell viability after 72 h of treatment in human (SJSA, SAOS-2, U2OS) and canine (D17, OSCA-2, OSCA-7.2, OSCA-16, OSCA-40, OSCA-36, OSCA-39.1, OSCA-50,) OS cells. c Time- and dose-dependent effects of AR-42 and SAHA on cell viability in human (U2OS and SAOS-2) and canine (D17, OSCA-2) OS cells. d Dose-dependent effects of AR-42 on cell viability after 72 h of treatment in human (SAOS-2, U2OS) and canine (D17, OSCA-2) OS cells and normal canine osteoblasts. Cells were exposed to AR-42 or SAHA at the indicated concentrations for 24, 48 or 72 h and cell viability assessed by MTT assay. Data presented are the average of triplicate determinations from three independent experiments