FIG. 1.

Routine histopathological analysis of lung tissue from the case report patient with LIP. (A) Widened alveolar walls are packed with a polymorphous lymphoid cellular infiltrate (broken arrow). Alveolar epithelium is intact (solid arrows). (B) Ciliated cells (arrows) line a small airway with mild infiltration of the stroma by lymphoid cells. (C to H) In situ hybridization for HHV-6 DNA in lung biopsy specimens from the case report patient (C to F) and from a patient with bronchiolitis obliterans with organized pneumonia (G and H). (C) Endothelial cells of a large vessel (vein). (D) Metaplastic bronchiolar epithelium lining the alveolar wall. (E) Inflammatory cells (monocytes/macrophages). (F and H) Alveolar pneumocytes. (G) Respiratory epithelium. The arrows indicate the positive signal from in situ hybridization.