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In mice gonadal sex determination occurs at ∼E11.5. At E11.5 the neural tube has formed the primary brain vesicles: Prosencephalon, Mesencephalon and Rhombencephalon. Between stages of E12.5 and E15.5, there is increased expansion of neuronal precursors and cell migration forming cortical layers. Simultaneously, neurons differentiate to allow for axonal branching and synapse formation.
