TABLE 1.
Antibodies against PERV proteins and pig cellular proteins detected in xenotransplantation patients
| Patient no. | Transplantation date | Mode of delivery | Wk before (−) or after transplantation | Presence of antibodies against:a
|
|||
|---|---|---|---|---|---|---|---|
| PERV
| |||||||
| gp70 | p27Gag | p15E | Pig proteins | ||||
| 1 | 1993 | Nonencapsulated islets | −214.6 | − | − | − | − |
| 15.9 | − | − | − | − | |||
| 460.3 | ++ | − | − | + | |||
| 2 | 1994 | Nonencapsulated islets | −6.9 | − | − | − | − |
| 2.0 | − | − | − | − | |||
| 14.4 | − | − | − | − | |||
| 410.0 | +++ | − | − | + | |||
| 3 | 1994 | Nonencapsulated islets | −0.4 | − | − | − | − |
| 2.7 | − | − | − | − | |||
| 15.4 | − | − | − | − | |||
| 427.6 | − | − | − | − | |||
| 4 | 1994 | Nonencapsulated islets | 2.4 | + | − | − | − |
| 163.6 | + | − | − | − | |||
| 394.4 | − | − | − | − | |||
| 5 | 1996 | Encapsulated islets | 2.7 | − | + | − | ++ |
| 44.3 | − | +++ | − | ++ | |||
| 312.0 | − | ++ | − | + | |||
| 6 | 1996 | Encapsulated islets | −2.3 | − | − | − | + |
| 2.6 | − | − | − | + | |||
| 42.9 | − | − | − | + | |||
| 311.9 | − | − | − | − | |||
| 7 | 2000 | Islets + Sertoli cells | 0.0 | − | − | − | − |
| 1.1 | − | − | − | + | |||
| 8 | 2000b | Islets + Sertoli cells | −13.0 | − | + | − | − |
| 1.9 | − | ++ | − | − | |||
| 6.0 | − | ++ | − | − | |||
| 19.1 | − | ++ | − | − | |||
| 9 | 2000 | Islets + Sertoli cells | −13.0 | − | − | − | − |
| 1.9 | − | − | − | + | |||
| 5.9 | − | − | − | + | |||
| 10 | 2000 | Islets + Sertoli cells | 1.7 | − | − | − | + |
| 6.6 | − | − | − | + | |||
| 15.3 | − | − | − | + | |||
| 11 | 2000 | Islets + Sertoli cells | −8.9 | − | ++ | − | − |
| 2.7 | − | ++ | − | +/− | |||
| 4.6 | − | ++ | − | +/− | |||
| 12 | 2001b | Islets + Sertoli cells | −1.1 | − | − | − | − |
| 1.7 | − | − | − | − | |||
| 6.6 | − | − | − | − | |||
| 15.3 | − | − | − | − | |||
| 13 | 2001 | Islets + Sertoli cells | −8.9 | − | − | − | − |
| 2.7 | − | − | − | + | |||
| 4.6 | − | − | − | + | |||
| 7.6 | − | − | − | + | |||
| 14 | 2001 | Islets + Sertoli cells | −6.0 | − | − | − | − |
| 2.7 | − | − | − | ++ | |||
a
The presence of antibodies is characterized as follows: −, none; +/−, none or weakly positive; +, weakly positive; ++, moderately positive; +++, strongly positive.
b
Microchimerism (presence of pig cells) was detected on one occasion; repeated bleeding after 1 month did not show any further evidence of PERV or pig cellular marker.