TABLE 1.
Comparison of amino acid substitutions and unique nucleotide changes of the Beaumont isolate to various published full-length amino acid sequencesa
| Amino acid substitution or nucleotide change | Virus strain or geographic location
|
||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beau- mont, Tex. | Orange, Tex. | NY 2001 | NJ 2000 MQ | MD 2000 Crow | NY 2000 Crow | NY 2000 Grouse | CN 1999 Mosquito | NY 382-99 | NY 1999 Equine | NY 1999 Human | Israel 1998 Stork | RO 97-50 Mosquito | Italy 1998 Equine | Astra- khan 1999 | Kenya 1998 | Volgo- grad 1999 | Volgo- grad 1999, brain | Volgo- grad 2000 | Eg101 1951 | Kunjin | Caucasus 1998 | Uganda 1937 | |
| E-76 | A | A | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T |
| NS1-94 | G | G | E | E | E | E | E | E | E | E | E | E | E | E | E | E | E | E | E | E | E | S | N |
| NS2A-90 | M | M | V | M | M | M | M | M | M | M | M | M | M | M | M | M | M | M | M | M | M | M | L |
| NS2A-138 | I | I | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V |
| NS3-188 | Q | Q | K | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q | Q |
| NS4B-173 | I | I | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V | V |
| NS5-526 | I | I | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T |
| 3′NCR-10494 | C | C | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | ND |
| 3′NCR-10768 | A | A | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | T | ND | T | T |
a
The Beaumont human isolate and nearby Orange County mosquito isolate share five amino acid substitutions and two noncoding nucleotide changes that are unique among published full-length amino acid sequences. See Fig. 1 for sources of genomic sequences. ND, not determined.